I am making 2 assumptions here;
1. the PC does not boot.
2. You have access to another PC.
The simplest thing to do, is to remove the hard drive from the PC, and install it as a secondary, or slave drive in another PC.
Back up your critical files to a new folder on the other PCs hard drive.
Then, back them up to CD or tape.
Remove the drive, and place it back into it's PC.
I recommend that you then go beyond a re-format of the hard drive, and start over clean.
Boot from a startup disk, and run fdisk
delete all logical drives and partitions.
re-boot,
run fdisk again, and partition the drive as desired
re-boot, and format at least the C: drive.
For more information on partitioning, check out www.aumha.org and www.fdisk.com/fdisk
Chas