I have seen this problem several times. The print spooler fails and the next thing to happen is it closes. Sometimes you have to reboot, sometimes BSD (Blue Screen Of Death)other times all installed printers are gone when you go back into printers. What has happened is the print driver was damaged (corrupted). Uninstalling the printer driver and reinstalling may help. Experiance has shown me the print driver entry's into the reg are also damage. When you unistall the driver it won't remove the entrys from the reg because they are not as they were when they are installed. Much like when you unistall a program that you have added things into the program folder. Windows won't delete the folder because there is data in it that it did not intially install. This is a well documentated problem. You can read about it and how to fix the reg in technet artical
http://support.microsoft.com/default.aspx?scid=kb;en-us;312052 That is Microsoft Knowledge Base Article - 312052