An advanced hybrid deterministic/metaheuristic approach to the synthesis of non-uniformly spaced linear printed patch antenna arrays is presented. A novel hybrid approach to the synthesis of non-uniformly spaced linear arrays of printed antennas is presented and thoroughly discussed in this paper. In order to account for parasitic mutual coupling between array elements, a dedicated optimization procedure in combination with a multiport network approach is adopted. Selected examples are included in order to assess the effectiveness and versatility of the proposed technique.